Goblet cells potentially act as sentinel cells and we comment on how this is potentially regulated.

Publication focussing on the complex relationship between an epithelial cell defect, microbiome translocation and mucosal inflammation.

Islet-endogenous and exogenous IL-22, by regulating oxidative stress pathways, suppresses oxidative and ER stress caused by cytokines or glucolipotoxicity in pancreatic beta cells.

Production of cytokines is beneficial for anti-viral responses; however, prolonged production further induces protein misfolding and leads to a cycle of stress and inflammation in the absence of pathogens.

In epithelial cells, STAT3 activation induced by IL-22 modulates antimicrobial and mucin secretion to maintain epithelial cell barrier integrity.